|
KMID : 1149220030110020125
|
|
Korean Journal of Oriental Medical Prescription
2003 Volume.11 No. 2 p.125 ~ p.134
|
|
|
Vasodilation Effect of the Water Extract of Gingko biloba, Acanthopanax senticosus and Augmented Four-Substance Decoctions in Rat Thoracic Aorta
|
|
Kim Hyung-Hwan
Park Soo-Yeon
Kang Soon-Ah
Kim Hong-Yeoul
Ahn Duk-Kyun
Park Seong-Kyu
|
|
|
Abstract
|
|
|
|
We have examined the relaxational response to the water extract of Angelica gigas NAKAI (AG), Gingko biloba LINNE (GB), Acanthopanax senticosus HARMS. (AP) and Augumented-Four-Substance Decoction (AG-FSD, GB-FSD, AP-FSD) in isolated thoracic aorta from sprague dawley(SD) rat. Rat thoracic aorta was investigated in vessel segments suspended for isometric tension recording by polygraph. Responses to AG, GB, AP and AG-FSD, GB-FSD, AP-FSD were investigated in vessels precontracted with 5-hydroxytryptamine(5-HT) were compared in vasodilation effect. We found that the thoracic aorta segments responded to AG, GB, AP and AG-FSD, GB-FSD, AP-FSD with a dose-dependent vasodilation. The 5-hydroxytryptamine induced contraction at 10-⁴M were inhibited by 26.3%, 75.8%, 87.5% and 6.9%, 22.6%, 30.8% after addition of the 0.1 g/mL water extract of AG, GB, AP and AG-FSD, GB-FSD, AP-FSD. In conclusion, AG, GB, AP and AG-FSD, GB-FSD, AP-FSD induced relaxation in the isolated rat thoracic aorta were composed of dose-dependent relaxation. AP-FSD has very potent vasodilation.
|
|
|
KEYWORD
|
|
|
vasodilation, Anglica gigas NAKAI, Gingko biloba LINNE, Acanthopanax senticosus HARMS, 5-hydroxytryptamine(5-HT)
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|